YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Age-related Changes of Brain Monoamine Contents and Monoamine Oxidase (MAO) Activities in Spontaneously Hypertensive Rats

선천성 고혈압 쥐의 연령별 뇌조직 중의 모노아민 함량및 MAO 활성 변화

  • Published : 1985.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The age-related changes of monoamine contents and monoamine oxidase (MAO) activities in the whole brain and blood pressures were measured and compared every week during the ages of 5 weeks to 12 weeks in two types of animals; (1) spontaneously hypertensive rats (SHR) and (2) normotensive Sprague-Dawley rats (NR). Blood pressures in SHR began to rise at the ages of 7 or 8 weeks and were significantly higher thereafter than in NR. Abnormally low MAO activities in the brain of SHR were detected from the ages of 8 weeks. Comparisons were also made between brain monoamine-norepinephrine, dopamine and 5-hydroxytrytamine contents of SHR and those of NR at the same ages throughout the test period. In SHR, none of those monoamine values was consistently higher or lower than in NR during the test period. Protein contents of the brain between SHR and NR were not significantly different at any ages. These observations suggest that the abnormally low MAO activities in SHR brain may be one of the underlying neurological factors for the susceptibilities to hypertension and the deficit of MAO activities may be due to the changes in properties rather than in amount of this enzyme.

Keywords

References

  1. Jap. Circ. J. v.27 Development of a strain of spontaneously hypertensive rats K.Okamoto;K.Aoki
  2. Jap. Heart J. v.14 The spontaneously hypertensive rat(SHR) An animal model for hypertensive research K.Okamoto
  3. Fed. Proc. v.43 Plasma norepinephrine and epinephrine levels in essential hypertension D.S.Goldstein;C.R.Lake
  4. Brain Res. v.167 Sympathetic hyperactivity and hypertension in adult spontaneously hypertensive rats despite early dorsolateral funicular lesions L.P.Schramm;H.J.Gunther;K.Mckenna;G.N.Barton
  5. Jap. Circ. J. v.42 The changes of plasma noradrenaline in SHR and experimental hypertensive rats T.Nishimura;InNishio;K.Motoki;S.Jimbo;M.Kuchii;Y.Masuyama
  6. Jap. Circ. J. v.42 Plasma catecholamine of spontaneously hypertensive rats C.H.Pak;M.Matsunaga;K.Morimoto;A.Hara;C.Kawai
  7. Jap. Heart J. v.22 Plasma adrenaline and noradrenaline concentrations of the spontaneously hypertensive rats C.H.Pak
  8. Circ. Res. v.38 no.SUP.Ⅱ Sympathetic Nerve Activity. Role in regulation of blood pressure in the spontaneously hypertensive rat W.V.Judy;A.M.Watanabe;D.P.Henry;H.R.Besch;W.R.Murphy;G.M.Hockel
  9. Nature v.258 Sympathoadrenal medullary activity in young, spontaneously hypertensive rats H.Grobecker;M.F.Roizen;V.Weise;J.M.Saavedra;I.J.Kopin
  10. Biochem. Pharmacol v.24 Adrenal medullary storage vesicles of the spontaneously hypertensive rat T.A.Slotkin;H.O.Green
  11. Jap. Heart J. v.16 Effect of increasing age on hemodynamics of spontaneously hypertensive rats J.Irichijima;Y.Numao;H.Suga
  12. Circ. Res. v.35 Neurogenic and humoral factors controlling vascular resistance in the spontaneously hypertensive rat L.T.Lais;R.A.Shaffer;M.J.Brody
  13. Circ. Res. v.48 Similarities of genetietic (spontaneous) hypertensive N.C.Trippodo;E.D.Frohlich
  14. Acta Physiol. Scand v.117 Age dependent alterations in the structurally determined vascular resistance, pre-to post-glomerular resistance ratio and glomerular filtration capacity in kidneys, as studies in aging normotensive rats and spontaneously hypertensive rats G.Gothberg;B.Folkow
  15. Circ. Res. v.40 Reflex regulation of sympathetic activity in the spontaneously hypertensive rat J.H.Coote;Y.Sato
  16. Circ. Res. v.51 The release of endogenous norepinephrine from the coccygeal artery of spontaneously hypertensive and Wistar-Kyoto rats M.P.Galloway;T.C.Westfall
  17. Fed. Proc. v.43 Central and peripheral noradrenergic tone in primary hypertension V.Dequattro;P.Sullivan;R.Minagawa;I.Kopin;J.Bornheimer;A.Frti;R.Barndt
  18. Fed. Proc. v.43 Effect of antihypertensive therapy on sympathetic nerve system activity in patients with essential hypertension B.Chernow;G.P.Zaloga;C.R.Lake;M.D.Coleman;M.G.Ziegler
  19. Fed. Proc. v.43 Perventricular forebrain mechanisms for blood pressure regulation J.Buggy;S.Huot;M.Pamnani;F.Haddy
  20. Life Sci. v.27 Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats S.Yamada;H.I.Yamamura;W.R.Roeske
  21. Fed. Proc. v.43 Autonomic degeneration and altered blood pressure control in humans M.G.Ziegler;C.R.Lake
  22. Fed. Proc. v.43 Pharmacologic tools for assessment of adrenergic nerve activity in human hypertension H.Ibsen;S.Julius
  23. J. Pharm. Pharmacol. v.28 Brain tyrosine hydroxylase activity and systolic blood pressure in rats treated with either deoxycorticosterone and salt or angiotensin P.Rylett;H.G.Dean;M.R.Lee
  24. J. Pharm. Pharmacol. v.33 Whole brain tyrosine hydroxylase activity during the development of deoxycorticosterone acetate-1% sodium chloride-induced hypertension in rats N.Jackson;P.A.Gulliver;H.G.Dean
  25. Jap. Heart J. v.14 Catecholamine content and metabolism in the spontaneously hypertensive rats M.Ozaki
  26. Naunyn-Schmiedebergs Arch. Pharmak. v.271 Genetically Hypertensive Rats: Relationship between the development of hypertension and the changes in norepinephrine turnover of peripheral and central adrenergic neurons K.Nakamura;M.Gerold;H.Thoenen
  27. Science v.191 Vascular and brain dopamine β-hydroxylase activity in young spontaneously hypertensive rats T.Nagatsu;K.Ikuta;Y.Numuta;T.Kato;M.Sano
  28. Jap. J. Pharmacol. v.31 no.SUP.Ⅰ Role of the central nervous system on development and maintenance of hypertension in spontaneously hypertensive rats (SHR) K.Nakamura
  29. Proc. Soc. Exp. Biol(N.Y.) v.150 Prevention of hypertension in the SH rat: Effect of differential central catecholamine depletion L.Erinoff;A.Heller;S.Oparil
  30. Life Sci. v.28 Central neurotransmitter receptor in hypertensive rats E.H.Cantor;S.Abraham;S.Spector
  31. Circ. Res. v.36 Brain amines and models in experimental hypertension J.P.Chalmers
  32. Annu. Rev. Pharmacol. Toxicol. v.16 Central neurotransmitter receptor in hypertensive rats A.Scriabine;B.V.Clineschmidt;C.S.Sweet
  33. Science v.170 Norepinephrine metabolism in brainstem of spontaneously hypertensive rats Y.Yamori;W.Lovenberg;A.Sjoerdsma
  34. Jap. Heart J. v.18 Noradrenaline-synthesizing enzymes in brain, serum, sympathetically innervated tissues, and adrenals of spontaneously hypertensive rats T.Nagatsu;T.Kato;Y.Numuta;K.Ikuta;M.Sano;I.Nagatsu;H.Umezawa;M.Matsuzaki;T.Takeuchi
  35. Jap. Heart J. v.18 Role on blood pressure regulation of noradrenergic neurons originating from the locus coeruleus in the Kyoto-Wistar rat M.Ogawa;Y.Fujita;M.Niwa;N.Takami;M.Ozaki
  36. Circ. Res. v.42 Changes in central catecholaminergic in the spontaneously (genetic) hypertensive rat J.M. Saavedra;H.Grobecker;J.Axelrod
  37. Jap. Heart J. v.19 Activation and central noradrenergic and adrenergic neurons in young and adult spontaneously hypertensive rats K.Nakamura;K.Nakamura
  38. Jap. Heart J. v.19 Serotonin metabolism in hypertension produced by chemical lesion of the locus coeruleus in the rat M.Ogawa;M.Ozaki
  39. Brain Res. v.185 Onset of hypertension in spontaneously hypertensive rats despite the depletion of spinal cord catecholamines A.D.Loewy;S.Mckellar;E.E.Swensson;W.M.Panneton
  40. J. Lab. Clin. Med. v.78 Validity of indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats J.M.Pfeffer;M.A.Pfeffer;E.D.Frohlich
  41. Method of Neurochemistry (Fried, R, ed.) V.P.Whittaker;L.A.Barker
  42. Proc. Soc. Exp. Biol. (N.Y.) v.89 Metabolism of 5-hydroxytryptamine by monoamine oxidase A.Sjoerdsma;T.F.Smith;T.D.Stevenson;S.Udenfriend
  43. Method of Biochemical Analysis v.6 S.Udenfriend;H.Weissbach;B.B.Brodie
  44. J. Biol. Chem. v.193 Protein measurement with the folin-phenol reagent O.H.Lowry;N.J.Rosebrough;A.L.Farr;R.J.Randall
  45. Anal. Biochem. v.23 A rapid and sensitive procedure for the combined assay of noradrenaline, dopamine, and serotonin in a single brain sample G.B.Ansell;M.F.Beeson
  46. Br. J. Pharmacol. v.39 Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain G.Curzon;A.R.Green
  47. Jap. J. Pharmacol. v.24 Levels of tyrosine and tryptophan in the plasma and brain of spontaneously hypertensive rats Y.Osumi;C.Tanaka;S.Takaori
  48. Life Sci. v.23 Serotonin-mediated cardiovascular responses to electrical stimulation of the raphe nuclei in the rat J.F.M.Smits;H.V.Essen;H.A.J.Struyker Boudier
  49. J. Pharmacol. v.24 Effect of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline levels and blood pressure in spontaneously hypertensive rats Y.Yamori;W.D.Jong;H.Yamabe;W.Lovenberg;A.Sjoerdsma
  50. J. Pharm. Exp. Ther. v.181 Central nervous system mechanism responsible for blood pressure elevation induced by p-chloro phenylalanine A.Ito;S.M.Schanberg
  51. Fed. Proc. v.34 Changes in monoamine oxidase and monoamine with human development and aging D.S.Robinson
  52. Behavior Genetics v.12 Monoamine oxidase (MAO) activity as a determinant in human neurophysiology J.E.Pintar;X.O.Breakefield
  53. Jap. Heart J. v.15 Amine oxidase activity in various tissues of the spontaneously hypertensive rats H.Kumagai;T.Utagawa;H.Yamada;Y.Yamori;K.Okamoto
  54. Yakhak Hoeji v.28 The relationship between presynaptic α-receptor and monoamine oxidase activity in the rat brain K.J.Lee;N.D.Kim;K.H.Ko