약학회지 (YAKHAK HOEJI)
- 제29권4호
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- Pages.220-222
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- 1985
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
원자흡광광도법에 의한 리팜피신의 정량에 관한 연구
Studies on the Determination of Rifampicin by Atomic Absorption Spectrophotometry
초록
Rifampicin reacts with cupric ion to produce rifampicin-Cu(II) chelate (2:1) at pH 6.5, which can be extracted with methylisobutylketone (MIBK). Therefore, rifampicin can be quantitatively, determined by measuring the quantity of Cu(II) in the organic phase by atomic absorption spectrophotometry. Because higher absorbance ratio was obtained in pH 6.0~7.0, buffer solution at pH 6.5 was used in this measurement. Linear relationship was found between absorbance and concentration in the range of 1.0~4.0
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