YAKHAK HOEJI (약학회지)
- Volume 29 Issue 1
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- Pages.39-42
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- 1985
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis and Reactivity of Zwitterionic Bicyclic Imidazo-thiazole Derivatives
Imidazo-thiazole 쯔비터 이온 유도체의 합성과 반응성
Abstract
Betaines of bicyclic imidazo-thiazoles were synthesized by the reaction of clectrophiles such as methyl isocyanate, methyl isothiocyanate, allyl isothiocyanate and ketene with 3-methyl and 3-phenyl-5, 6-dihydroimidazo [2,1-b] thiazole. In this reaction, the methyl group which was substituted at 3-position increased the yields of the products in comparison with those from phenyl group substituted substrates. Also, the betaines reacted with methyl iodide to give imidazo-thiazolium salts which were unstable at high temperature and converted the quaternary ammonium salts of original biheterocycles.
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