Archives of Pharmacal Research
- 제8권1호
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- Pages.21-30
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- 1985
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Antimicrobial and Antineoplastic Tyrosine Metabolites from a Marine Sponge, Aplysina fistularis
초록
Examination of the constituents of a marine sponge, Aplysina fishtularis, indicated that brominated tyrosine metabolites were mainly responsible for antimicrobial and antineoplastic activities. Halogenated tyrosine metabolites, 2, 6-dibromo-(2), 2-bromo-3-chloro-(3) and 2, 6-dibromo-(5), 5-a mino-2-bromo-6-chloro-(6) and 5-amino-2, 6-dich-loro-(7) 4-hydroxy-2-cyclohexenone-4-acetic acid lactams were identified as the major antineoplastic and antimicrobial principles. Many other brominated tyrosine metabolites were also confirmed, but they did not show antimicrobial and antineoplastic activities.
키워드