Journal of Pharmaceutical Investigation
- 제15권1호
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- Pages.8-14
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- 1985
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Preparation and Identification of Crystal Modification of Piroxicam
- Suh, Jung-Jin (YuHan Research Center, YuHan Corporation) ;
- Kim, Bong-Hee (Department of Pharmacy, Chungnam National University) ;
- Ko, Jung-Gil (YuHan Research Center, YuHan Corporation)
- 발행 : 1985.03.20
초록
Data obtained from X-ray diffractometry, thermal analysis, IR spectroscopy and microscopic observation were used for the identification and characterization of four crystalline modifications of piroxicam. form a was crystallized from sodium hydroxide-hydrochloric acid and from c was obtained by crystallization from toluene. Form b and d was crystallized from methanol under the different temperature conditions. Relative rates of dissolution and solubility of four crystal forms of piroxicam in distilled water were measured.
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