생약학회지 (Korean Journal of Pharmacognosy)
- 제16권4호
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- Pages.248-252
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- 1985
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Isolation of Toxic Saponins from the Roots of Patrinia scabiosaefolia
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
- Choi, Jae-Sue (Natural Products Research Institute, Seoul National University) ;
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
- 발행 : 1985.12.30
초록
During the biological screening of Chinese drugs, it was found that alcoholic extract of the roots of Patrinia scabiosaefolia (Valerianaceae) caused a significant prolongation of hexobarbital-induced sleeping time and elevation of serum transaminase activities accompanied by severe histopathological changes in the hepatic tissues in mice on three day pretreatments. The systematic fractionation of the methanol extract monitoring by bioassay led to isolation of toxic saponins such as