Korean Journal of Pharmacognosy (생약학회지)
- Volume 16 Issue 3
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- Pages.129-135
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- 1985
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Potential Antidotes for T-2 Toxin Poisoning
- Chang, I.M. (Natural Products Research Institute, Seoul National University) ;
- Mar, W. (Natural Products Research Institute, Seoul National University) ;
- Kim, J.H. (Natural Products Research Institute, Seoul National University) ;
- Gotvandi, H.N. Kalandi (Graduate School of Public Health, Seoul National University) ;
- Zong, M. (Graduate School of Public Health, Seoul National University)
- Published : 1985.09.30
Abstract
In order to search for potential antidotes for T-2 toxin poisoning, seven Chinese herbal drug extracts and five natural constituents were tested on mice intoxicated with T-2 toxin. When extracts of Panax ginseng and Atractylodes japonica (500 mg/kg) were administered p.o. once 3 hrs before and once 1 hr after T-2 toxin treatment, a 30% complete survival rate was noted. In case of Paeonia albiflora var. typica, a 30% complete survival rate was also produced at a dose of 250 mg/kg. Other extracts, Glycyrrhiza uralensis, Scutellaria baicalensis, Rehmannia glutinosa and Plantago asiatica exhibited no significant protection from the T-2 toxin poisoning. A nucleoside, thymidine showed protective activity against T-2 toxin toxicity and it produced a 40% complete survival rate when administered i.p. once 0.5 hr after T-2 toxin treatment. Other natural constituents, aucubin, vitamin C and E, and lipoic acid did not show any significant protective activities.
Keywords
- T-2 toxin poisoning;
- antidote;
- Paeonia albiflora var. typica;
- Panax ginseng;
- Atractylodes japonica;
- thymidine