Effects of Panax Ginseng on the Development of Morphine Induced Tolerance and Dependence (II) -Effects of Ginseng Butanol Fraction on the Development of Morphine Induced Tolerance and Dopamine Receptor Supersensitivity in Rats-

Morphine의 내성(耐性) 및 의존성(依存性) 형성(形成)에 미치는 인삼(人蔘)의 효과(II) -인삼(人蔘)의 Butanol 분획이 흰쥐의 Morphine 내성(耐性) 및 Dopamine 수용체(受容體) 초과민성(超過敏性) 형성에 미치는 영향(影響)-

Intraperitoneal administration of ginseng butanol fraction(GBF) to chronic morphinization in male Sprague-Dawley rats inhibited the development of tolerance to the analgesic effect and hyperthermic action of morphine. Rats were rendered tolerant to morphine by subcutaneous multiple morphine injections for a period of 8 days. The development of tolerance was evidenced by the decreased analgesic response to morphine and inhibition of tolerance by the greater analgesic response. Concomitant administration of morphine with GBF blocked the tolerance to the hyperthermic effect of morphine as evidenced by elevation of body temperature by morphine. Dopamine receptor sensitivity was enhanced in morphine tolerant rats as measured by apomorphine induced in spontaneous motor activity. GBF administration also blocked dopamine receptor supersensitivity induced by chronic morphinization.