The Korean Journal of Physiology
- 제19권1호
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- Pages.35-48
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- 1985
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- 0300-4015(pISSN)
측뇌실내로 투여한 Thiopental Sodium의 가토 신장기능에 미치는 영향
Influence of Intracerebroventricular Thiopental Sodium on the Renal Function in Conscious Rabbit
- Hong, Ki B. (Department of Physiology, Jeonbug National University Medical School) ;
- Cho, Kyung W. (Department of Physiology, Jeonbug National University Medical School)
- 발행 : 1985.06.30
초록
One of most frequently used anesthetic agents is barbiturate derivatives. Pentobarbital or thiopental sodium have been used most frequently in the laboratory or clinical practice. There have been reports on the renal effects of barbiturate anesthesia in human and laboartory animals. Renal effects of thiopental sodium anesthesia, however, are still controversial. One of the discrepancies may be derived from the doses used. It has been reported that subanesthetic small dose of thiopental sodium influences the renal function directly. To clarify possible central effects of very small amounts of thiopental sodium on the renal function, experiments have been done in conscious rabbits. Thiopental sodium was infused into the lateral cerebroventricle for 10 minutes. Intracerebroventricular thiopental sodium induced increased urinary volume, glomerular filtration rate and renal plasma flow by doses of
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