The Korean Journal of Physiology
- 제19권1호
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- Pages.25-33
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- 1985
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- 0300-4015(pISSN)
무마취가토 신동맥내 투여에 의한 Trifluoperazine의 신장기능에 미치는 영향
Effects of Renal Arterial Trifluoperazine on the Renal Function in Conscious Rabbit
- Koh, Gou Y. (Department of Physiology, Jeonbug National University Medical School) ;
- Cho, Kyung W. (Department of Physiology, Jeonbug National University Medical School)
- 발행 : 1985.06.30
초록
Renal arterial infusion of renotropic agents has been a very useful technique in the renal function studies. This type of experiments have usually been conducted in the large animals such as dogs and sheep. In these animals a catheter can be placed in the site without much disturbances of renal blood flow. Rabbits as an experimental model, however, caused a disturbances of renal blood flow by a catheterization of renal artery by its properties. Therefore we have developed a new technique that allows a simple and selective access to one side of renal arteries and the other as a control, without any disturbances of renal function. The distance between the both bifurcations of renal arteries on abdominal aorta is about 7 mm. To locate the tip of catheter on one side renal artery, ascending cannulation performed via femoral artery was done. We did an experiment with the technique to clarify the effect of calmodulin inhibitor on the renal function. One of the phenothiazine derivatives, trifluoperazine known as a powerful calmodulin inhibitor. Trifluoperazine, actual dose ranges of
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