Journal of Radiation Protection and Research
- Volume 10 Issue 2
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- Pages.122-129
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- 1985
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- 2508-1888(pISSN)
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- 2466-2461(eISSN)
Drug Toxicities of S-2-(W-aminoalkylamino) ethyl and S-2, W-diaminoalkyl Isothiuronium Bromides and their Potent Radioprotective Effects
S-2, - (W-aminoalkylamino) ethyl 및 S-2, W-diaminoalkyl Isothiuronium Bromide 의 약독성(藥毒性)과 방사선장해방호(放射線障害防護) 효과
- Kim, You-Sun (Reactor Chemistry Laboratory, Korea Advanced Energy Research Institute) ;
- Kim, Suc-Won (Reactor Chemistry Laboratory, Korea Advanced Energy Research Institute)
- Published : 1985.12.20
Abstract
S-2, W-diaminopentyl isothiuronium bromide and relevant thiophosphate derivative were prepared starting from both phthalimide and l-ornithinic acid. Drug toxicities of the prepared isothiuronium bromide and S-2-(W-aminoalkylamino) ethyl isothiuronium bromides were tested through ICR male mice, 4 and 8 weeks old and weighing
S-2, W-diaminopentyl isothiuronium bromide 및 그 thiophosphate 유도체는 phthalimide 또는 l-ornithine 산(酸)으로부터 출발(出發)하여 합성(合成)되었다. 합성(合成)한 isothiuronium bromide 및 S-2-(W-aminoalkylamino)ethyl isothiuronium bromide의 약독성(藥毒性)을 체중(體重) 25-35g,
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