YAKHAK HOEJI (약학회지)
- Volume 28 Issue 4
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- Pages.207-215
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- 1984
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Effects of a Chinese Traditional Medicine, Ssang Wha Tang, on the Pharmacokinetics of Sulfobromophthalein in the Rats of Hepatic Failure Induced by Carbon Tetrachloride
雙和湯이 四鹽化炭素에 의한 肝障害 Rat에서 Sulfobromophthalein의 體內動態에 미치는 영향
- Ann, Byung-Nak (College of Pharmacy, Seoul National University) ;
- Kim, Shin-Keun (College of Pharmacy, Seoul National University) ;
- Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
- Chung, Youn-Bok (College of Pharmacy, Seoul National University)
- Published : 1984.08.01
Abstract
Effects of Ssang Wha Tang (SWT), a blended Chinease traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) in the rats of hepatic failure induced by carbon tetrachloride were examined. The disposition of plasma BSP in carbon tetrachloride-treated rats (Group I) and in carbon tetrachloride+SWT-treated rats (Group II) followed a three-compartment model, while those in control group followed two-compartment model. GOT, GPT level and some pharmacokinetic paramiters like plasma clearance but except distribution volume (Vdss) recovered in Group II compared to Group I. Therefore, SWT seemed to have an apparent restoring effect of hepatic function damaged by carbon tetrachloride treatment. From the fact that Vdss of BSP in Group II was considered as an one of the probable mechanisms. More intensive increase in BSP-free fraction (
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