Archives of Pharmacal Research
- 제7권2호
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- Pages.133-136
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- 1984
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of Higenamine, A Cardiotonic Principle of Aconite Root
- Chang, Ki-Churl (Seoul National University) ;
- Choi, Sook-Yun (College of Medicine and Natural Products Research Institute) ;
- Lim, Jung-Kyoo (College of Medicine and Natural Products Research Institute) ;
- Park, Chan-Woong (College of Medicine and Natural Products Research Institute)
- 발행 : 1984.12.01
초록
Higenamine (I), cardiotonic principle of Aconite root, was synthesized from 4-methoxy-phenylacetic acid (II) and .betha.-(3, 4-dimethoxyphenyl)-ethylamine (IV). Condensation of IV with 4-mehoxyphenylacetyl chloride (III) was followed by cyclodehydration yielding 1-(4'-methoxybenzyl)-6, 7- dimethoxy-3, 4-dihydroisoquinoline (VI). Reduction of VI to 1, 2, 3, 4-tetrahydroisoquinoline (VII) and subsequent demethylation provided desired product higenamine, 1-(4'-hydroxybenzyl)-6, 7- dihydroxy-1, 2, 3, 4, -tetrahydroisoquinoline.
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