Radiation Oncology Journal

The Korean Society for Radiation Oncology (대한방사선종양학회)
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An Experimental Study on the Effect of Repeated Hyperthermia on the Radiation Injury

반복 온열료법이 방사선조사효과에 미치는 영향에 관한 실험적 연구

  • Choi, Young-Hi (Department of Radiology, College of Medicine, Seoul National University) ;
  • Park, Charn-Il (Department of Radiology, College of Medicine, Seoul National University) ;
  • Han, Man-Chung (Department of Radiology, College of Medicine, Seoul National University)
  • 최 영희 (서울대학교 의과대학 방사선과학교실) ;
  • 박찬일 (서울대학교 의과대학 방사선과학교실) ;
  • 한만청 (서울대학교 의과대학 방사선과학교실)
  • Published : 1984.06.01
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Abstract

To evaluate the influence of prior heat treatment on the thermal enhancement of irradiation effect after hyperthermia, an experimental study was carried out using a total of 80 mice. Hyperthermia was carried out at $43^{\circ}C$ for 40 minutes and was repeated with various intervals. A single dose of 3,000 rad was delivered on skin of mouse tail immediately after the second hyperthermia. The skin changes of the irradiated mouse tail were observed from 7th to 35th post-irradiation days, and the skin scores were analyzed. The results are as follows, 1. The radiation damage on mouse skin increased significantly when radiation was combined with hyperthermia. 2. The radiation damage after repeated hyperthermia is significantly less than that after single hyperthermia, when the interval is 1 to 6 days. 3. As a result, thermal tolerance persists from 1 through 6 days after the initial hyperthermia.

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