Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Synthesis and Antifungal Activity of 3-Oxo-1, 2-benzisothiazole-1, 1-dioxide Derivatives

3-Oxo-1,2-benzisothiazole-1,1-dioxide유도체의 합성 및 항규성

  • Yoon, Yong-Jin (Department of Chemistry, College of Natural Science, Gyeongsang National University) ;
  • Park, Chang-Suk (Department of Plant Protection, College of Agriculture, Gyeongsang National University) ;
  • Kim, In-Kyu (Department of Chemistry, Sung Kyun Kwan University)
  • 윤용진 (경상대학교 자연과학대학 화학과) ;
  • 박창석 (경상대학교 농과대학 식물보호학과) ;
  • 김인규 (성균관대학교 이과대학 화학과)
  • Published : 1984.06.30
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Abstract

Some derivatives of 3-oxo-1,2-benzisothiazole-1,1-dioxide were synthesized, and their antifungal activities against Pyricularia oryzae was determined by the agar medium dilution method. $I_{50}$ values of the candidate derivatives were shown to be as follows; 3-chloro(37.8ppm), 2-chloro(318.7ppm), MCS(20.1ppm), 2-allyl(946.2ppm), 3-(p-nitrophenyloxy) (35.4ppm), 3-(o-nitrophenyloxy) (11.8ppm), 3-(p-aminophenyloxy) (1643.2ppm), 2-chloromethyl(192.7ppm) and 2-hydroxymethyl derivative(248.4ppm).

3-Oxo-1,2-benzisothiazole-1, 1-dioxide의 몇몇 유도체를 합성하고 이들 유도체의 Pyricuria oryzae에 대한 항균성을 조사하였다. 이들 유도체의 $I_{50}$값은 각각 다음과 같다 ; 3-chloro (37.8ppm), 2-chloro (318.7ppm), MCS (20.1ppm), 3-(P-nitrophenyloxy) (35.4ppm), 3-(o-nitrophenyloxy) (11.8ppm), 3-(p-aminophenyloxy) (1643.2ppm) 2-allyl (946.2ppm), 2-(hydroxymethyl) (248.4), 2-chloromethyl 유도체 (192.7ppm)

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