Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지

Interaction of Erythrosine with Several Pharmaceutical Gelatins

Erythrosine과 수종(數種) 젤라틴간의 상호작용(相互作用)

  • Min, Shin-Hong (Central Research Laboratories, Dong-A Pharmaceutical Company) ;
  • Kwon, Jong-Won (Central Research Laboratories, Dong-A Pharmaceutical Company) ;
  • Jheong, Yeoub (Central Research Laboratories, Dong-A Pharmaceutical Company)
  • 민신홍 (동아제약 중앙연구소) ;
  • 권종원 (동아제약 중앙연구소) ;
  • 정엽 (동아제약 중앙연구소)
  • Published : 1984.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

The interactions of FD & C Red No.3 (erythrosine) in 1 or 2% concentrations with various types of pharmaceutical gelatins were studied. In visible region spectroscopy type A gelatin showed 6 nm bathochromic shift in ${\lambda}_{max}$ of erythrosine, but no shifts were observed in other gelatins. Various results were obtained in the decrease of absorbance from 0.06 to 0.25. In dissolution study, the gelatin that showed the greatest spectral change exhibited the worst profile. From above results, it is concluded that erythrosine interacted to the greatest extent with type A gelatin and in the case of type B gelatin the degree of the interaction in different according to their specifications.

Keywords