Journal of Pharmaceutical Investigation
- Volume 14 Issue 4
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- Pages.156-160
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- 1984
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Pharmacokinetics of Acetaminophen in Rabbits with Carbon Tetrachloride Induced Hepatic Failure
간장병태(肝臟病態) 가토(家兎)에서 아세트아미노펜의 약물동태학적(藥物動態學的) 연구(硏究)
- Lee, Jin-Hwan (College of Pharmacy, Cho Sun University) ;
- Choi, Jun-Shik (College of Pharmacy, Cho Sun University) ;
- Burm, Jin-Pil (College of Pharmacy, Cho Sun University)
- Published : 1984.12.20
Abstract
The pharmacokinetics of acetaminophen administered intravenously(20mg/kg) was investigated in the rabbits of carbon tetrachloride induced hepatic failure. The blood level, the total AUC and the biological half life of acetaminophen were increased significantly in hepatic failure rabbits compared with those of normal rabbits. The urinary excretion and the overall elimination rate of acetaminophen were decreased significantly in hepatic failure rabbits. There was significant relationship between GOT value and AUC or biological half life of acetaminophen.
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