Journal of Pharmaceutical Investigation
- Volume 14 Issue 2
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- Pages.92-103
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- 1984
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Debrisoquine on Renal Function in Rabbits
Debrisoquine이 가토신장기능(家兎腎臟機能)에 미치는 영향(影響)
- Ko, Suk-Tai (College of Pharmacy, Cho Sun University) ;
- Park, Jung-Hee (College of Pharmacy, Cho Sun University)
- Published : 1984.06.20
Abstract
The action of debrisoquine on renal function in rabbits was studied. 1. When debrisoquine was given into ear vein, it did not affect on renal functin with smaller doses of 0.1 or 0.3mg/kg, while with higher dose of 1.0mg/kg it elicited the significant decrease of urine flow, renal plasma flow and glomerular filtration rate, and the increase of filtration fraction, and at the same time sodium excreted in urine, FENa (fractional excretion of sodium) and osmolar clearance were significantly decreased, and then it exhibited the increase of
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