Fenbufen 좌제(坐劑)의 물리화학적(物理化學的) 성상(性狀) 및 생체이용률(生體利用率)에 관(關)한 연구(硏究)

Study on Physicochemical Characteristics and Bioavailability of Fenbufen Suppositories

This investigation was designed to determine the release of fenbufen from suppositories and their bioavailability in rabbits. Suppositories containing fenbufen were made by the fusion method with Witepsol H-15, Wecobee and PEG 1540 base. Displacement value, weight variation, content uniformity, melting point and melting time were determined for preformulation of the fenbufen suppositories. The release rates were determined with the KP dissolution apparatus and with cellophane tube dialysis device and were increased in order of PEG 1540, Witespol H-15 and Wecobee. The bioavailabilities of fenbufen after rectal administration were also increased in order of PEG 1540, Witespol H-15 and Wecobee.