난용성약물(難溶性藥物)인 Indoprofen의 ${\beta}-Cyclodextrin$복합체(複合體) 형성(形成)에 따른 생체이용률(生體利用率)의 개선(改善)에 관한 약제학적(藥劑學的) 연구(硏究) (제2보)(第二報)

Pharmaceutical Studies on Improved Bioavailability of Indoprofen by ${\beta}-Cyclodextrin$ Complexation ( II )

The pharmaceutical characteristics of solid indoprofen inclusion complex such as dissolution, permeation through a cellophane membrane, model analysis of interfacial tranesfer, absorption behaviors in rat intestine, and the plasma concentration of indoprofen after oral administrations to rabbits were examined in comparison with those indoprofen alone. The inclusion complex obtained by freeze-drying method showed the higher dissolution rate and membrane permeability among the test powders, and increased significantly the amont of indoprofen absorbed in rat intestine and the levels of plasma concentration of indoprofen after oral adminstrations to rabbits. The increase of bioavailability of $indoprofen-{\beta}-cyclodextrin$ complex was considered due to the increased solubility and dissolution rate of solid powder form.