약학회지 (YAKHAK HOEJI)
- 제28권5호
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- Pages.293-297
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- 1984
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- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Tranylcypromine의 겉보기 해리항수(解離恒數) 및 분배계수(分配係數)
Apparent pKa and Partition Coefficient of Tranylcypromine
- Kang, Gun-Il (College of Pharmacy, Sookmyung Women's University) ;
- Chung, Soon-Young (College of Pharmacy, Sookmyung Women's University)
- 발행 : 1984.10.30
초록
The pKa' of tranylcypromine was determined by potentiometric titration and ultraviolet spectrophotometric method and found to be 8.08 and 8.15, respectively. The Papp of tranylcypromine between n-heptane and aqueous buffer solution was measured to be 0.90 at pH 7.48 and 4.50 for Pm. The pKa' of tranylcypromine obtained by means of the partition method was 8.13.
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