A Histopathological Observation on the Local Side Reaction following the Intramuscular Injection of Iron Preparations in Guinea pigs

철분근육주사후에 일어나는 국소자극반응에 관한 병리조직학적 관찰

This study was conducted to observe the local irritation histopathologically following the intramuscular injection of iron preparations in guinea pigs. Necropsy findings were edema, hemorrhage and darkish brown pigmentation around the injection sites. On the microscopic examination, the muscle fibers near the injection sites became pale staining or uniformly eosinophilic, indicating necrosis of the fibers, which were occasionally filled with granular bluish-staining material. The nuclei were swollen or pyknotic. Infiltrations of heterophils and macrophages containing iron were evident around the necrotized tissues and the injected iron compounds. Fibrosis was often seen between the affected muscle fibers, and this change was considered as secondary inflammatory process.