약학회지 (YAKHAK HOEJI)
- 제27권4호
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- Pages.309-314
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- 1983
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
아미노산으로부터 3-(2-Chloroethyl) hydantoin들의 합성과 그들의 항암작용 평가
Synthesis and Antitumor Evaluation of 3-(2-Chloroethyl)-hydantoins from Some Amino Acids
초록
Six hydantoin derivatives, 3-(2-chloroethyl) hydantoin (6a), 3-(2-chloroethyl)-5-isopropylhydantoin (6b), 3-(2-chloroethyl)-5-isobutylhydantoin (6c), 3-(2-chloroetbyl)5-(2-butyl) hydantoin (6d), 3-(2-chloroethyl)-5-benzylhydantoin (6e), 3-(2-chloroethyl)-5-(indolyl-3-methyl) hydantoin (6f), were prepared by the treatment of the corresponding salt of amino acids with 2-chloroethyl isocyanate in cold water, followed by refluxing in concentrated HCl solution. Anticancer activity of the synthesized hydantoin derivatives were examined on murine leukemia L1210 cells growing in Fischer medium. Among them, 3-(2-chloroethy)-5-isobutyl-hydantoin (6c) showed substantially low
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