약학회지 (YAKHAK HOEJI)
- 제27권4호
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- Pages.257-261
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- 1983
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
약물과 생체고분자간의 상호작용(VI) Nalidixic Acid 및 Probenecid와 우혈청 단백간의 결합에 관한 연구
Drug-Biomacromolecule Interaction (VI) Binding of Nalidixic Acid and Probenecid to Bovine Serum Albumin
초록
Binding of nalidixic acid which is used primarily in the treatment of urinary infection and probenecid which is used as a uricosuric agent to bovine serum albumin were studied using difference spectrophotomeric method. 2-(4'-Hydroxybenzeneazo) bcnzoic acid as a spectrophotometric probe was used for measuring the binding of nalidixic acid and probenecid to bovine serum albumin. The association constants of nalidixic acid and probenecid were
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