Preparation of $\etha$-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine

$\etha$-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine의 합성

  • 김정균 (부산대학교 자연과학대학) ;
  • 조인섭 (부산대학교 자연과학대학)
  • Published : 1983.06.01

Abstract

A copper complex of $\epsilon$-N-[(2-chloroethyl)carbamoyl]-L-lysine was prepared by the treatment of the L-lysine copper complex with 2-chloroethyl isocyanate in cold water. Within the L-lysine copper complex molecule, the $\alpha-amino$ and carboxyl groups are bounded to $Cu^{2+}$ but the $\epsilon-amino$ group is free and can react with carbamoylating agents. A potential antitumor agent, $\epsilon-N-[(2-chloroethyl)$ nitrosocarbamoyl]-L-lysine was synthesized by nitrosation of this copper complex with Na $NO_{2}$ in anhydrous formic acid, followed by the passage of $H_{2}$S gas.

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