Journal of Pharmaceutical Investigation
- Volume 13 Issue 3
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- Pages.100-103
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- 1983
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Enhancement of Dissolution from Pharmaceutical Preparation of Hydrophobic Drugs ( II ) -Dissolution Rates of Sulpiride-Polyethylene Glycol Coprecipitates-
Sulpiride-Polyethylene Glycol Coprecipitates의 용출속도(溶出速度)에 관한 연구(硏究)
- Ku, Young-Soon (College of Pharmacy, Ewha Womans University)
- 구영순 (이화여자대학교 약학대학)
- Published : 1983.09.20
Abstract
Coprecipitates of sulpiride and polyethylene glycol (PEG) decrease the dissolution rate of sulpiride and the degree of decrease is reversely proportional to molecular size of PEG and proportional to increase of PEG ratios in coprecipitates. The physical mixtures of sulpiride and PEG increase the dissolution rate of sulpiride.
Keywords