Pharmacokinetics of Nalidixic Acid in $CCl_4-Toxicated$ Rabbit

병태(病態) 토끼에서의 Nalidixic Acid의 약물동태학적(藥物動態學的) 연구(硏究)

In order to elucidate the effects of Panax Ginseng on the pharmacokinetic parameters of nalidixic acid in a patho-physiological changes, the kinetics of the disappearance of the drug from the blood, appearance in the bile and urinary excretion were studied in $CCl_4-toxicated$ rabbits. The pharmacokinetics of the drug nalidixic acid in rabbits were modeled by a two compartment. Total saponin, water extract from Panax Ginseng, significantly decreased biliary and urinary excretion of nalidixic acid.