Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Ethoxy-hydroxy-benzoic Acid; A Platelet Antiaggregating Substance from Acanthopanacis Cortex

오가피로부터 혈소판 응집억제작용 물질 Ethoxy-hydroxy-benzoic Acid의 분리

  • Yun, Hye-Sook (Natural Products Research institute, Seoul National University) ;
  • Kim, Sun-Ok (Natural Products Research institute, Seoul National University) ;
  • Kim, Jae-Hoon (Natural Products Research institute, Seoul National University) ;
  • Cho, Han-Ik (College of Pharmacy, Seoul National University)
  • Published : 1983.12.30
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Abstract

The BuOH fraction prepared from the methanol extract of Acanthopanacis Cortex showed inhibitory activity against ADP-induced platelet aggregation. The inhibitory activity remained in ether layer when the BuOH fraction was refluxed with 5% aq. HCl-EtOH (1 : 1 mixture) and extracted with ether. From the ether layer, ethoxy-hydroxy-benzoic acid $(m.p.\;128{\sim}130^{\circ}C)$, a platelet antiaggregating substance, was isolated.

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