대한약리학회지 (The Korean Journal of Pharmacology)
- 제19권2호
- /
- Pages.57-67
- /
- 1983
- /
- 0377-9459(pISSN)
해명(海冥) 회종편(回腫片)에서 Morphine과 Naloxone 작용(作用)에 미치는 전해질(電解質)의 영향(影響)
Influences of Electrolytes on the Action of Morphine and Naloxone in Guinea-pig Ileum
- Kwon, Yong-Chon (Dept. of Psychiatry, Jeonbuk National University, Medical School) ;
- Eun, Hong-Bae (Dept. of Psychiatry, Jeonbuk National University, Medical School) ;
- Cho, Kyu-Park (Dept. of Pharmacology, Jeonbuk National University, Medical School)
- 발행 : 1983.12.30
초록
Guinea-Pig의 myenteric plexus-longitudinal muscle preparation에서 morphine과 naloxone 효과(效果)에 미치는 전해질(電解質)의 영향(影響)을 관찰(觀察)하였다. 표본(標本)은 Krebs-Henseleit bicarbonate tufter solution 으로 채운 organ bath에 현수(懸垂)하고 0.2Hz로 전기자극(電氣刺戟)하였다. Morphine은 전기자극(電氣刺戟)에 의(依)한 근편수축(筋片收縮)을 억제(抑制)하였으며, 이때
The influence of electrolyte concentrations on the action of morphine and naloxone was studied in the myenteric plexus-longitudinal muscle preparation of guinea-pig ileum to examine whether opiate receptor binding obseved in vitro with homogenates represents binding to the pharmacological receptor. The preparations were suspended in a modified Krebs-Henseleit bicarbonate buffer solution and electrically stimulated at 0.2 Hz. Morphine inhibited electrically evoked contractions; the concentration of morphine required for a 50-percent inhibition was 190 nM. This inhibitory action of morphine was potentiated in a medium containing lower concentrations of :
키워드