대한약리학회지 (The Korean Journal of Pharmacology)
- 제19권2호
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- Pages.25-34
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- 1983
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- 0377-9459(pISSN)
가토 문맥에 있어서 비 코린성, 비 아드레나린성 억제성 반응에 관한 약리학적 특징
Pharmacological Characteristics of Non-cholinergic, Non-adrenergic Inhibitory Responses in Rabbit Portal Vein
- Jung, Hyun-Ok (Department of Pharmacology, College of Medicine, Busan National University) ;
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Hong, Ki-Whan
(Department of Pharmacology, College of Medicine, Busan National University)
- 발행 : 1983.12.30
초록
가토의 문맥 절편에서 비 코린성-비 아드레나린성 이완반응에 대한 약리학적 성질을 규명하여 다음과 같은 결과를 얻었다. 1) 가토 문맥 절편에 있어서 비 코린성-비 아드레나린성 전기자극반응은 자극빈도의 증가에 따라 예민하게 증가하였으며,
In this isolated study, it was aimed to elucidate the pharmacological properties of non-cholinergic, non-adrenergic inhibitory responses in the longitudinal strips of rabbit portal vein. 1) The portal vein responded inhibitory to electrical field stimulation in a frequency - and calcium-dependent manner after pretreatment with atropine, guanethidine and ergotamine, simultaneously. 2) When exogenous ATP, ADP, adenosine and cyclic AMP were added, respectively, they only showed the relaxations in the higher concentration without mimicing or affecting the inhibitory response induced by the electrical stimulation. The antagonist of purine substances, neither quinine nor isobutyl-methyl xanthine did influence on the relaxation. 3) The inhibitory response was significantly increased in the presence of
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