항암활성을 지닌 Streptococcus pyogenes의 적정 살균조건에 관한 연구(제 2 보)생육에 미치는 소독제와 항생물질 처리의 영향

Studies on the optimal conditions of Sterilization for Streptococcus pyogenes (Part II) Effect of Disinfectant and Antibiotics on Growth

전보에서 선정한 Streptococcus pyogenes 의 살균제, 항생물질 처리에 따른 적정 살균조건을 검토하여 다음과 같은 결자를 얻었다. 과산화수소 농도가 0.2%일 때는 생존균의 감소에 영향이 없었으나 0.4, 0.5, 0.8, 1%로 농도를 증가함에 따라 생존균의 감소가 급격하게 일어났으며 1 % 농도 처리시 10분만에 생존율은 0.5% 미만이었다. Erythromycin, tetracycline, cephalerin 각각의 MIC (Minimum inhibitory concentration) 는 0.78, 0.39, 3.125 $\mu\textrm{g}$/$m\ell$이었다.

The optimal conditions of sterilization for Streptococcus pyogenes treated with disinfectant and antibiotics were investigated. The survivors of Streptococcus pyogenes had no effect at the concentration of 0.2% hydrogen peroxide but decreased abruptly when the concentration increased from 0.4% to 1.0% Minimum inhibitory concentration values of 0.78, 0.39 and 3.125 $\mu\textrm{g}$/$m\ell$ for erythromycin, tetracycline and cephalexin, respectively, were obtained for Streptococcus pyogenes when incubated at 37 $^{\circ}C$ for 24 hrs. Tetracycline and cephalexin showed bactericidal effect against Streptococcus pyogenes, whereas erythromycin did bacteriostatic effect.