약학회지 (YAKHAK HOEJI)
- 제26권1호
- /
- Pages.25-27
- /
- 1982
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
s-Triazine의 Ring Transformation에 의한 5-FU의 합성
Synthesis of 5-Fluorouracil by Ring Transformation of s-Triazine
초록
We had reported that s-triazine can readily be converted into the corresponding 5-substituted pyrimide. In order to develop new synthetic method of 5-fluorouracil, we tried to replace eliminating fragment, 1, 3-dimethylurea, by fluoroacetamide, which was expected to undergo nucleophilic attack by proton extraction of both .alpha.-hydrogen and aminohydrogen by lithium diisopropylamide (LDA). We found that 5-fluorouracil could be transformed from s-triazine under strong base condition like LDA as well as other 5-substituted pyrimidines.
키워드