Cyclophosphamide가 백서하악과두의 성장에 미치는 영향에 관한 실험적 연구

EXPERIMENTAL STUDY OF THE EFFECTS ON THE GROWTH OF MANDIBULAR CONDYLE FOLLOWING CYCLOPHOSPHAMIDE ADMINISTRATION IN RAT

In this study, effects of cyclophosphamide on the growth of the mandibular condyle head were investigated with Spraque-Dawley rats of the 28 days of age. Rats were devided into four groups. Three were used as experimental groups, and one as control. Each rat in experimental group was injected intraperitoneally with cyclophosphamide repeatedly three times, 20mg/kg for the first group, 40mg/kg for the second, and 60mg/kg for the third each time. Rats in control group were injected with physiological saline in the same method. Rats in each group were sacrificed at 5, 10, and 15 days following the last injection. The specimens were stained with H-E, toluidine blue, PAS, and alcian blue. The results were as follows; 1. In experimental group, with increasing the injection doses, the thickness of the condylar cartilage from the transitional zone to the hypertrophic zone became thinner than in control group. 2. Weaker metachromasia to toluidine blue and less positive reaction to PAS were seen. 3. In primary marrow cavity the fewer trabecular was formed, The direction of trabecular formation became obscuerer, and the lower density of bone was resulted in.