Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Liver-protective Activities of Alisol Compounds against $CCl_4$ Intoxication

택사(澤瀉)로부터 분리(分離)한 Alisol 성분(成分)의 간(肝) 보호작용(保護作用)

  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
  • Kim, Young-Soo (Natural Products Research Institute, Seoul National University) ;
  • Yun, Hye-Sook (Natural Products Research Institute, Seoul National University) ;
  • Kim, Sun-Ok (Natural Products Research Institute, Seoul National University)
  • Published : 1982.09.30
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Abstract

Alisol A monoacetate, alisol B monoacetate, alisol C monoacetate and alisol B were isolated from Alismatis Rhizoma, which is a herbal drug used frequently in the oriental prescriptions. Potential liver-protective activities of the isolated alisol compounds were evaluated against $CCl_4-induced$ liver damage. The results obtained from liver microsomal enzyme assay, measurement of serum glutamic pyruvic transaminase (EC 2.6.1.2) and serum triglyceride content indicated that alisol A,B and C monoacetates showed significant liver-protective activities against $CCl_4$ poisoning. Alisol B monoacetate exhibited slightly higher activity than that of alisol B.

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