Korean Journal of Pharmacognosy (생약학회지)
- Volume 13 Issue 2
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- Pages.62-69
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- 1982
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Toxicological Evaluation of Medicinal Plants Used for Herbal Drugs (IV) -Acute Toxicity and Antitumor Activities-
한국산 생약의 약리작용 및 독성연구 (제4보) -급성독성 및 항암작용-
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Chang, Il-Moo
(Natural Products Research Institute, Seoul National University)
;
- Kim, Jae-Hoon (Natural Products Research Institute, Seoul National University) ;
- Han, Dae-Suck (College of Pharmacy, Seoul National University)
- Published : 1982.06.30
Abstract
Fiftythree species(35 families and 52 genera)of Korean medicinal plants which have been frequently used in oriental herb prescriptions or have been used as folklorics were evaluated on their short term acute toxicity and potential antitumor activities against P-388 murine lymphocytic leukemia model in vivo. Among these plants Acorus gramineus (Araceae), Agrimonia pilosa (Rosaceae), Aralia elata (Araliaceae), Dryopteris crassirhizoma (Aspidiaceae), Syringa reticulata (Oleaceae) and Calystegia japonica (Convolvulaceae) exhibited potent acute toxicity resulting from severe weight loss and death. Agrimonia pilosa (Rosaceae) showed about 33% of increased life span in comparison with that of control group mouse, but others exhibited no significant antitumor activities.
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