한국균학회지 (The Korean Journal of Mycology)
- 제10권3호
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- Pages.111-117
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- 1982
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- 0253-651X(pISSN)
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- 2383-5249(eISSN)
한입버섯의 항암성분(抗癌成分)에 관한 연구(硏究)
Antitumor Components of Cryptoporus volvatus
- 김병각 (미국 퍼듀대학교 약학대학 의약화학 및 생약학교실) ;
- 제임스 로버스 (미국 퍼듀대학교 약학대학 의약화학 및 생약학교실) ;
- 정경수 (서울대학교 약학대학 미생물약품화학교실) ;
- 정희수 (서울대학교 약학대학 미생물약품화학교실) ;
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최응칠
(서울대학교 약학대학 미생물약품화학교실)
- Kim, Byong-Kak (Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University) ;
- Robbers, James E. (Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University) ;
- Chung, Kyeong-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
- Chung, Hee-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
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Choi, Eung-Chil
(Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
- 발행 : 1982.09.30
초록
The carpophores of Cryptoporus volvatus collected in Gyeong-gi Province of Korea were extracted with water and a protein-polysaccharide fraction was obtained after dialysis and lyophilization. The antitumor activity of this fraction was tested against sarcoma 180 implanted in A-strain mice. The tumor inhibition ratio was 80.4% in case of the high dose group (50mg/kg, ip, 10 days) and 70.3% in the low dose group (20mg/kg, ip, 10 days). The proteinpolysaccharide fraction was chemically analyzed and was found to be a complex of a protein which was 18.2% of the fraction when determined by Lowry-Folin method, and a polysaccharide which was 55.3% of ther fraction when determined by Anthrone method. Their subunits were identified as four monosaccharides and 18 amino acids by gas-liquid chromatography and amino acid autoanalysis.
키워드