The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Antitumor Components of Cryptoporus volvatus

한입버섯의 항암성분(抗癌成分)에 관한 연구(硏究)

  • Kim, Byong-Kak (Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University) ;
  • Robbers, James E. (Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University) ;
  • Chung, Kyeong-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Chung, Hee-Soo (Department of Microbial Chemistry, College of Pharmacy, Seoul National University) ;
  • Choi, Eung-Chil (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
  • 김병각 (미국 퍼듀대학교 약학대학 의약화학 및 생약학교실) ;
  • 제임스 로버스 (미국 퍼듀대학교 약학대학 의약화학 및 생약학교실) ;
  • 정경수 (서울대학교 약학대학 미생물약품화학교실) ;
  • 정희수 (서울대학교 약학대학 미생물약품화학교실) ;
  • 최응칠 (서울대학교 약학대학 미생물약품화학교실)
  • Published : 1982.09.30
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Abstract

The carpophores of Cryptoporus volvatus collected in Gyeong-gi Province of Korea were extracted with water and a protein-polysaccharide fraction was obtained after dialysis and lyophilization. The antitumor activity of this fraction was tested against sarcoma 180 implanted in A-strain mice. The tumor inhibition ratio was 80.4% in case of the high dose group (50mg/kg, ip, 10 days) and 70.3% in the low dose group (20mg/kg, ip, 10 days). The protein­polysaccharide fraction was chemically analyzed and was found to be a complex of a protein which was 18.2% of the fraction when determined by Lowry-Folin method, and a polysaccharide which was 55.3% of ther fraction when determined by Anthrone method. Their subunits were identified as four monosaccharides and 18 amino acids by gas-liquid chromatography and amino acid autoanalysis.

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