Stability Analysis of Ampicillin Trihydrate in Solid-State

고체상태에서 Ampicillin Trihydrate의 안정성에 관한 연구

  • 김종국 (서울대학교 약학대학) ;
  • 곽효성 (주식회사 종근당 중앙연구소) ;
  • 신희종 (주식회사 종근당 중앙연구소)
  • Published : 1981.03.01

Abstract

Penicillin derivatives have a stability problem by hydrolysis of their .betha.-lactam ring. At high temperature, crystal water is released from penicillin derivatives, especially ampicillin trihydrate and concerns itself in hydrolysis. Penicillin derivatives having crystal water show different crystal states and different stability according to the variation of different condition on the process of manufacturing. The stability of ampicillin trihydrate in solid states was determined. Physico-pharmaceutical properties of this compound were determined by using IR spectra, X-ray powder diffraction and differential thermal analysis (DTA).

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