Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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The transformation of ginsenosides by acid catalysis in gastric pH

  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Park, Myung-Hwan (Natural Products Research Institute, Seoul National University) ;
  • Han, Yong-Nam (Department of Chemistry, College of Natural Science, Kangweon National University) ;
  • Woo, Lin-Keun (Natural Products Research Institute, Seoul National University) ;
  • Ushio-Sankawa (The Faculty of Pharmacy, The University of Tokyo) ;
  • Shoji-Yahara (Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University) ;
  • Osamu-Tanaka (Natural Products Research Institute, Seoul National University)
  • Published : 1981.06.01
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Abstract

The ginsenosides of Korean ginseng decomposed profoundly to produce artifact products of prosapogenin $A_{1}$, $A_{2}$ and $A_{3}$ from ginsenoside Rg$_{1}$, prosapogenin $C_{1}$, $C_{2}$ and $C_{3}$ from ginsenoside Re, and prosapogenin E$_{1}$, E$_{2}$ and E$_{3}$ from ginsenoside Rb$_{1}$ by the acid treatment under physiological condition such as 37.deg.C incubation in 0.1 N HCI. 2. The chemical structures of the artifact substances were determined by the analysis CMR and mass spectra of TMS derivatives as following; table omitted.

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