Journal of Pharmaceutical Investigation
- 제11권2호
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- Pages.16-19
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- 1981
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Lorazepam제제(製劑)의 용출속도(溶出速度)에 미치는 인자(因子)
Some Factors Influencing the Dissolution Rate of Lorazepam Formulations
- Lee, Chang-Ki (Department of Pharmacy. The National Medical Center) ;
- Song, In-Jung (Department of Pharmacy. The National Medical Center) ;
- Choi, Jung-Young (Department of Pharmacy. The National Medical Center) ;
- Suh, Sung-Won (Department of Pharmacy. The National Medical Center)
- 발행 : 1981.06.20
초록
The effect of diluents and lubricants on the dissolution rate of lorazepam was studied. The results were as following. 1. An average order of dissolution rate can be stated as; lactose> avicel> starch> kaolin. 2. The effects of lubicants is not significant generally but in the case of starch the dissolution rate is greatly effected by magnesium stearate.
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