The Korean Journal of Pharmacology (대한약리학회지)
- Volume 17 Issue 1 Serial No. 28
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- Pages.9-15
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- 1981
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- 0377-9459(pISSN)
Studies on the Positive Inotropic Mechanism of Aconiti Tuber
부자 강심성분의 작용기전에 관한 연구
- Kim Myung-Suk (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Kim Yong-Sik (Department of Pharmacology, College of Medicine, Seoul National University)
- Published : 1981.06.01
Abstract
Aconiti tuber butanol fraction, which is isolated from the chloroform insoluble and water soluble extract of Aconitum volubile, has been recently known to have a potent positive inotropic effect in the isolated cardiac muscle preparations of various animals. The positive inotropic mechanism of Aconiti tuber butanol fraction, in relation with the external calcium, was studied using the isolated cat papillary muscle. The positive inotropic effect was dependent on the calcium concentration in the nutrient medium, and a synergistic relation could be demonstrated between Aconiti tuber butanol fraction and the external calcium. The inotropic effect of
부자성분중 강심효과를 나타내는 부자부타놀분획의 작용기전을 심근수축기전이 있어서 중심적인 역활을 하는 칼슘이온과의 상호관계에서 검토하였으며 아울러 동물생체내 혈동력학에 대한 영향을 관찰하였다. 부자부타놀분획 적출 고양이 유두근표본의 수축력증가작용에 있어서 심근외칼슘과 상승적이었으며 부자부타놀분획
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