Journal of Preventive Medicine and Public Health
- 제13권1호
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- Pages.41-46
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- 1980
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
연폭로시 혈구용적치 및 혈색소치의 변화
The Effects of Lead Exposure on Hematocrit ana Hemoglobin
- 이세훈 (가톨릭 의과대학 예방의학교실)
- Lee, Se-Hoon (Department of Preventive Medicine, Catholic Medical College)
- 발행 : 1980.10.01
초록
In order to study the effect of lead exposure on the hematocrit and hemoglobin values in accordance with the level of lead exposure, twenty-four Sprague-Dawley rats were equally divided into four groups of six rats each. Lead acetate disolved in glucose was injected intraperitoneally six times a week, for four weeks with dose of 0.05 mg/kg/day for group I, 0.5 mg/kg/day for group II, and 5 mg/kg/day for group III. Control group was injected glucose only. Blood samples for the checking of the hematocrit and hemoglobin values, were taking from tail vein of rats before lead injection and on the third, seventh, fourteenth, twenty-first, and twenty-eighth days after lead injection. And also, the concentration of lead and ALA in urine were checked for evaluating the lead absorption. The results were as follows: 1. The alteration of the hematocrit and hemoglobin values of the group I was not significant as that of the control group. 2. In group II, the hematocrit values were significantly decreased from the fourteenth day after lead injection, and the hemoglobin values were decreased from the twenty-first day after lead injection when the concentration of lead in urine was elevated more than
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