The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Study on Blood Cortisol in Patients treated with Oral Corticosteroid Drugs

경구 Corticosteroid계 약물 치료한 환자에 있어서 혈중 cortisol에 관한 연구

  • Park, J.H. (Department of Radiology and Nuclear Medicine, Yonsei University College of Medicine) ;
  • Kim, K.W. (Department of Radiology and Nuclear Medicine, Yonsei University College of Medicine) ;
  • Yoo, H.S. (Department of Radiology and Nuclear Medicine, Yonsei University College of Medicine) ;
  • Lee, J.T. (Department of Radiology and Nuclear Medicine, Yonsei University College of Medicine) ;
  • Park, C.Y. (Department of Radiology and Nuclear Medicine, Yonsei University College of Medicine) ;
  • Ryu, K.J. (Department of Pharmacology, Yonsei University College of Medicine)
  • 박정희 (연세대학교 의과대학 방사선과학교실) ;
  • 김기황 (연세대학교 의과대학 방사선과학교실) ;
  • 유형식 (연세대학교 의과대학 방사선과학교실) ;
  • 이종태 (연세대학교 의과대학 방사선과학교실) ;
  • 박창윤 (연세대학교 의과대학 방사선과학교실) ;
  • 유경자 (연세대학교 의과대학 약리학교실)
  • Published : 1980.06.30
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Abstract

This is an analysis of 32 patients who received long continuous corticosteroid drug due to some diseases. Patients were collected from June 1976 to March 1980. Blood cortisol level, variation of diurnal rhythm and side effects were studied. The Result as follows: 1. Side effects were observed in 24 patients(75%) and most common complaint was obesity. 2. Diurnal rhythm analysed by Doe's method shows abnormal diurnal rhythm is 21 out of 32(66%). 3. Mean durations or therapy of abnormal diurnal rhythm and normal diurnal rhythm were $55.7{\pm}4.4$ months and $43.9{\pm}7.0$ months respectively which shows statistically significant difference. 4. Mean cortisol value of steroid treated patients were lower than normal. 5. Reverse diurnal rhythm was 4 out of 21 patients. 6. 8 A.M. cortisol value is lower than 2 times of 8 P.M. in all patients who showed abnormal diurnal rhythm except one.

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