Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Complexes of Polyvalent Metal Ions (Ⅶ). Complexes of Cadmium, Cobalt and Nickel with Hydroxycarboxylic Acids in Aqueous, Ethanol-Water and Acetone-Water Solutions$^*$

  • Park, Joon-W. (Korea Research Institute of Chemical Technology) ;
  • Mukherjee, C. (University of Calcutta, Department of Chemistry)
  • Published : 1980.09.30
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Abstract

A general spectroscopic method is described for studies on the complex formation between metal ions and ligands, and is applied to $Cu^{2+}$ and $Ca^{2+}$binding to glycosaminoglycans. The order of binding constants for both ions is heparin >dermatan sulfate >chondroitin sulfate. The electrostatic forces are shown to be the predominant factor in the interaction. The 2- to 3-fold higher affinity for $Cu^{2+}$ than for $Ca^{2+}$ is obtained for heparin and dermatan sulfate, but little difference for chondroitin sulfate. These results are explained as chelation of both carboxyl and sulfate groups to $Cu^{2+}$ in former cases. The difference of binding constants among glycosaminoglycans is related to proposed various biological functions of the biopolymers.

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References

  1. Connective Tissues: Macromolecular Structure and Evolution M. B. Mathews;A. Kleinzeller(ed.);G. F. Springer(ed.);H. G. Wittmann(ed.)
  2. Biopolymers v.12 B. Lages;S. S. Stivala
  3. Arch. Biochem. Biophys. v.180 B. Chakrabarti
  4. Biopolymers v.17 N. Figueroa;B. Chakrabarti
  5. Arch. Biochem. Biophys. v.191 D. C. Mukherjee;J. W. Park;B. Chakrabarti
  6. Biochem. J. v.85 J. R. Dunstone
  7. Can. J. Biochem. v.49 E. A. MacGregor;J. M. Bowness
  8. Physiol. Rev. v.58 W. D. Comper;T. C. Laulent
  9. J. Biol, Chem. v.193 E. S. Boyd;W. F. Neuman
  10. Biochem. J. v.170 S. Vannucchi;M. D. Rosso;C. Cella;P. Urbano;V. Chiarugi
  11. Proc. Natl. Acad. Sci. U.S.A. v.60 C. Woodward;E. A. Davidson
  12. Chemistry and Molecular Biology of the Intercellular Matrix v.2 M. B. Mathews;E. A. Balazs(ed.)
  13. Biochem. Biophys. Acta v.544 J. W. Park;B. Chakrabarti
  14. J. Amer. Chem. Soc. v.77 A. M. Kotliar;H. Morawetz
  15. J. Phys. Chem. v.59 H. P. Gregor;L. B. Lattinger;E. M. Loebl
  16. Biochem. Biophys. Acta v.37 M. B. Mathews
  17. Arch. Biochem. Biophys. v.104 M. B. Mathews
  18. Hoppe-Sevlers Z. Physiol. Chem. v.327 E. Buddecke;R. Drzeniek
  19. Fed. Proc. v.36 J. Blackwell;K. P. Schodt;R. A. Gelman
  20. Fed. Proc. v.36 T. Olivecrona;G. Bengtsson;S. E. Marklund;U. Lindahl;M. Hook
  21. Proc. Of the First NATO Advanced Study Institute on Charged and Reactive Polymers Polyelectrolytes G. S. Manning;Forges-les-Eaux(ed.);E. Selegny(ed.);M. Mandel(ed.);U. P. Strauss(ed.)
  22. Biochem. Biophys. Res. Commun. v.75 C. P. Dietrich;L. O. Sampaio;O. M. S. Toledo;C. M. F. Cassaro
  23. Biochem. Biophys. Acta v.498 L. O. Sampaio;C. P. Dietrich;O. G. Filho