회첨 엑기스의 혈압에 미치는 영향(I)

Effects of Siegesbeckiae Herba Extracts on the Blood Pressure of Rabbits(I)

희첨(Siegesbeckiae Herba)은 진득찰(Siegesbeckiae pubescens Makino)의 잎을 말하며 한방에서 중풍, 전신마비, 반신불수, 부종등에 사용되어 왔다. 이에 관한 연구로는 한등이 diterpene계의 불합물을 분리하였고 이 diterpene계중의 한 성분이 실험적 신성 고혈압을 유기한 백서에 항고혈압작용이 있음을 보고한바 있으나 이의 고혈압 활료제로의 실용성 여부에 관하여서는 확인된 바가 없어 고혈압 치료제 개발의 일환으로서 화학적 성분 연구에 우선하여 약리학적으로 그 본태를 파악하고저 수성 및 알콜성 엑기스를 축출하여 가토에 대하여 이 실험을 시행하였다.

To investigate the effects of Siegesbeckiae Herba on the blood pressure, this study was carried out in the whole and the spinal rabbits, using its water and ethanol extracts. When Sigesbeckiae Herba water extract (SGWE) and ethanol extract (SGEE) were administered into the whole rabbits by route of e ear vein, both of them produced fall of blood pressure. The difference between these two extracts was that SGEE is more potent than SGWE. The depressor effects of SGWE and SGEE were not affected by vagoto minization but inhibited by pretreatment of atropine. The depressor responses of the whole rabbits to intravenous SGWE and SGEE were weakened by treatment of animals with bethanidine or phentolamine but not by propranolol. Pretreatment of the whole rabbits with diphenhydramine significantly weakened the d depressor effects of SGEE. Infusion of SGWE and SGEE in the whole rabbits did not influence the pressor effects caused by angiotensin, norepinephrine or carotid artery occlusion. SGEE, when given into the lateral ventricle of the whole rabbits or into the vein of the spinal rabbits, elicited fall of blood pressure, respectively.