A Comparative Study of the Influence of Miflumic Acid and Phenylbutazone on Warfarin-Plasma Protein Binding

약-약 상호작용 연구(IV) Warfarin의 혈장단백 결합에 대한 Niflumic Acid 및 Phenylbutazone의 영향 비교

To determine in vitro effects of phenylbutazone and niflumic acid on warfarin binding to rabbit serum protein, warfarin was added to the rabbit plasma, and the bound fraction was determined by warfarin-protein complex fluorescence. The bound fraction was decreased by phenylbtazone and niflumic acid. From this effect niflumic acid was found to have the more potent ability to displace warfarin from protein binding sites than phenylbutazone.