YAKHAK HOEJI (약학회지)
- Volume 24 Issue 1
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- Pages.1-10
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- 1980
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Studies on the Mechanism of Resistance to and Mode of Action of Viomycin in Mycobacterium smegmatis
Mycobacterium smegmatis를 이용한 Viomycin의 내성 및 작용 기전에 관한 연구
Abstract
Viomycin inhibited polypeptide biosynthesis, initiation complex formation and translocation of peptidyl-tRNA on ribosomes derived from a sensitive strain of Mycobacterium smegmatis (R-15), but not significantly on ribosomes from viomycin-resistant mutants(R-31 and R-43). The inhibition of translocation was stronger than that of initiation complex formation in the sensitive strain. The binding of [
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