Journal of Pharmaceutical Investigation
- 제10권3호
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- Pages.20-26
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- 1980
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Sulpyrin과 Ampicillin의 상호작용(相互作用)에 관(關)한 연구(硏究)
The Studies on the Interaction of Sulpyrin and Ampicillin
초록
The purpose of this paper was to study the effect of sulpyrin on the absorption, excretion, metabolism, and protein binding of ampicillin in the small intestine of the rats and rabbits. The results are as follows; The absorption of ampicillin in small intestine of rats was increased by the combination of sulpyrin and ampicillin. The blood level of ampicillin in rabbits was elevated by oral administration of sulpyrin. The bioavailability of ampicillin was increased by simultaneous administration of sulpyrin and ampicillin. The urinary excretion of ampicillin was slightly decreased by combined administration of sulpyrin. The blood level of ampicillin was decreased and the urinary excretion was increased by long term administration of sulpyrin. On the other hand, metabolising enzyme
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