Journal of Pharmaceutical Investigation
- Volume 10 Issue 3
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- Pages.1-4
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- 1980
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Comparision of the Blood Concentration of Ampicillin and Lysinomethylene Ampicillin in Man
Ampicillin과 Lysinomethylene Ampicillin의 혈중농도비교(血中濃度比較)
- Kim, Johng-Kap (College of Pharm., Chung-Ang Univ.) ;
- Kim, Young-Il (Yuhan Co.) ;
- Kim, Bong-Hee (Seoul Metro Govert. Insti. of Public Health)
- Published : 1980.09.20
Abstract
In order to increase the solubility and antibacterial activity of ampicillin, the lysinomethylene ampicillin trihydrate was synthesized. The blood concentrations of ampicillin trihydrate and synthetic lysinomethylene ampicillin trihydrate were determined in 10 healthy male volunteers by using large plate method with Sarcina lutea ATCC 9341. The mean blood concentration of synthetic lysinomethylene ampicillin trihydrate was higher ca. 1.3 times than that of ampicillin trihydrate in 10 test subjects after oral administration.
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