Mathematical Description of the Volume of Distribution in the Isolated Organ

The model of an isolated organ system has been developed to simulate the kinetic behavior of drug levels in an acting organ or site. The model is developed from basic considerations of drug distribution with hemodynamical and pharmacokinetical meanings. Model: It is considered a situation in which non-metabolic drug substance is injected into the arterial inflow of an isolated organ at constant rate. The volume of distribution and the concentration of drug in the venous outflow can be mathematically expressed as a function of time.